The other targets of alcohol use disorder: The systemic effects of alcohol abuse

Authors

DOI:

https://doi.org/10.7203/metode.12.18426

Keywords:

alcohol use disorder, immunity, neurological damage, cardiovascular system, epigenetics

Abstract

Drinking alcohol is an established and normalised practice in our society, even though it can physically harm us. High-risk alcohol drinking patterns can increase the chance of negative consequences for the drinkers or their environment. The liver is by far the organ most affected by alcohol abuse; however, alcohol use disorder is a systemic disease which affects a wide range of organs and psychological processes. Other systems that can be affected by continued alcohol consumption include the immune, neurological, and cardiovascular systems. In addition, alcohol can lead to epigenetic alterations that may be transmitted from one generation to the next.

Downloads

Download data is not yet available.

Author Biographies

Arantza Sanvisens, Germans Trias i Pujol Research Institute (IGTP) in Badalona (Spain).

Graduate in statistics from the Autonomous University of Barcelona and graduate in documentation from the Open University of Catalonia. She is a researcher in the Addictive Disorders Network at the Germans Trias i Pujol Research Institute (IGTP) in Badalona (Spain), a programme included in the Thematic Networks for Cooperative Research in Health funded by the Carlos III Health Institute in Madrid.

Robert Muga, Germans Trias i Pujol Research Institute (IGTP) in Badalona (Spain).

PhD in Medicine and Surgery from the Autonomous University of Barcelona, with a Master’s degree in Public Health from the Johns Hopkins University (USA). He works as an internist and researcher at the Internal Medicine Department of the Germans Trias i Pujol University Hospital in Badalona (Spain) and as a professor of Medicine at the Autonomous University of Barcelona.

References

Anstee, Q. M., Daly, A. K., & Day, C. P. (2015). Genetics of alcoholic liver disease. Seminars in Liver Disease, 35(04), 361–374. https://doi.org/10.1055/s-0035-1567832

Berkel, T. D. M., & Pandey, S. C. (2017). Emerging role of epigenetic mechanisms in alcohol addiction. Alcoholism: Clinical and Experimental Research, 41, 666–680. https://doi.org/10.1111/acer.13338

Carrigan, M. A., Uryasev, O., Frye, C. B., Eckman, B. L., Myers, C. R., Hurley, T. D., & Benner, S. A. (2015). Hominids adapted to metabolize ethanol long before human-directed fermentation. Proceedings of the National Academy of Sciences of the United States of America, 112(2), 458–463. https://doi.org/10.1073/pnas.1404167111

Cederbaum, A. I. (2012). Alcohol metabolism. Clinics in Liver Disease, 16(4), 667–685. https://doi.org/10.1016/j.cld.2012.08.002

Chamorro, A. J., Rosón-Hernández, B., Medina-García, J.-A., Muga-Bustamante, R., Fernández-Solá, J., Martín-González, M.-C., Seco-Hernández, E., Novo-Veleiro, I., Suárez-Cuervo, C., Mateos-Díaz, A. M., Monte-Secades, R., Machado-Prieto, B., Puerta-Louro, R., Prada-González, C., Fernández-Rial, Á., Sabio-Repiso, P., Vázquez-Vigo, R., Antolí-Royo, A.-C., Gomila-Grange, A., … Laso, F.-J. (2017). Differences between alcoholic and nonalcoholic patients with Wernicke encephalopathy: A multicenter observational study. Mayo Clinic Proceedings, 92(6), 899–907. https://doi.org/10.1016/j.mayocp.2017.02.019

Degenhardt, L., Charlson, F., Ferrari, A., Santomauro, D., Erskine, H., Mantilla-Herrara, A., Whiteford, H., Leung, J., Naghavi, M., Griswold, M., Rehm, J., Hall, W., Sartorius, B., Scott, J., Vollset, S. E., Knsudse, A. K., Haro, J. M., Patton, G., Kopec, J., … Vos, T. (2018). The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet Psychiatry, 5(12), 987–1012. https://doi.org/10.1016/S2215-0366(18)30337-7

García-Calvo, X., Bolao, F., Sanvisens, A., Zuluaga, P., Tor, J., Muga, R., & Fuster, D. (2020). Significance of markers of monocyte activation (CD163 and sCD14) and inflammation (IL-6) in patients admitted for alcohol use disorder treatment. Alcoholism: Clinical and Experimental Research, 44(1), 152–158. https://doi.org/10.1111/acer.14228

Leger, A. S. S., Cochrane, A. L., & Moore, F. (1979). Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. The Lancet, 313(8124), 1017–1020. https://doi.org/10.1016/S0140-6736(79)92765-X

Observatorio Español de las Drogas y las Adicciones. (2020). INFORME 2020 Alcohol, tabaco y drogas ilegales en España. https://pnsd.sanidad.gob.es/

Rao, R., & Topiwala, A. (2020). Alcohol use disorders and the brain. Addiction, 115(8), 1580–1589. https://doi.org/10.1111/add.15023

Sanvisens, A., Zuluaga, P., Rivas, I., Rubio, G., Gual, A., Torrens, M., Short, A., Álvarez, F. J., Tor, J. Farré, M., Rodríguez de Fonseca, F., & Muga, R. (2017). Patients with alcohol use disorder: initial results from a prospective multicenter registry in the Spanish Network on Addiction Disorders. CohRTA Study. Adicciones, 30(4), 931. https://doi.org/10.20882/adicciones.931

Szabo, G., & Saha, B. (2015). Alcohol’s effect on host defense. Alcohol Research: Current Reviews, 37(2), 159–170. https://pubmed.ncbi.nlm.nih.gov/26695755/

Wood, A. M., Kaptoge, S., Butterworth, A., Willeit, P., Warnakula, S., Bolton, T., Paige, E., Paul, D. S., Sweeting, M., Burgess, S., Bell, S., Astle, W., Stevens, D., Koulman, A., Selmer, R. M., Verschuren, W. M. M., Sato, S., Njølstad, I., Woodward, M., … Danesh, J. (2018). Risk thresholds for alcohol consumption: Combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies. The Lancet, 391(10129), 1513–1523. https://doi.org/10.1016/S0140-6736(18)30134-X

Zuluaga, P., Sanvisens, A., Teniente-Serra, A., El Ars, O., Fuster, D., Quirant-Sánchez, B., Martínez-Cáceres, E., & Muga, R. (2020). Loss of naive T lymphocytes is associated with advanced liver fibrosis in alcohol use disorder. Drug and Alcohol Dependence, 213, 108046. https://doi.org/10.1016/j.drugalcdep.2020.108046

Downloads

Published

2022-02-02

How to Cite

Sanvisens, A., & Muga, R. (2022). The other targets of alcohol use disorder: The systemic effects of alcohol abuse. Metode Science Studies Journal, (12), 71–77. https://doi.org/10.7203/metode.12.18426
Metrics
Views/Downloads
  • Abstract
    1803
  • Untitled (Español)
    0
  • PDF
    772

Issue

Section

Willpower hijacked. The science of addictions

Metrics

Similar Articles

> >> 

You may also start an advanced similarity search for this article.