Ozone therapy immunomodulatory effect in the selective immunoglobulin A deficiency.

Authors

  • Jacqueline Diaz-Luis “Roberto Rodriguez Fernandez” University Hospital. POBox 67220, Moron
  • Silvia Menendez-Cepero Prodanza Center. Ozone Clinic. Havana
  • Consuelo Macias-Abrahan Hematology and Immunology Institute. Ap 8070, POBox 10800 Havana

DOI:

https://doi.org/10.7203/jo3t.1.1.2015.12161

Keywords:

ozone thrapy, inmunology, selective IgA deficiency, immunological parameters, cytokines, subcutaneous Hebertrans

Abstract

The aim of this work is to study the ozone therapy effect in the selective immunoglobulin A deficiency. Taking into account that ozone is able to stimulate several biological systems, to modulate cytokines levels and to enhance immunoglobulin production, a phase II, controlled and randomized, clinical trial was performed. Forty patients were divided at random into 2 groups of 20 patients each: Ozone – received 42 sessions by rectal insufflations during three months, using scaling doses. Control – received subcutaneous Hebertrans during three months. Patients were evaluated at the beginning and one and six months later. The IgA improved, with significant difference (p=0.04) between both groups. The blood levels of IgG were increased significantly (p=0.03) in the group treated with ozone compared to the control group. Leukocyte activity improved significantly (p=0.04) one month later, achieving 97 % of normal values. The clinical evolution was satisfactory in 87 and 80 % of the children that received ozone and Hebertrans, respectively without side effects reported.

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Published

2015-12-15

How to Cite

Diaz-Luis, J., Menendez-Cepero, S., & Macias-Abrahan, C. (2015). Ozone therapy immunomodulatory effect in the selective immunoglobulin A deficiency. Journal of Ozone Therapy, 1(1). https://doi.org/10.7203/jo3t.1.1.2015.12161
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