Therapeutic effects of Ozone therapy in adult periodontitis treatment, subtypes I and II.
DOI:
https://doi.org/10.7203/jo3t.1.1.2015.12160Keywords:
ozone therapy, periodontitis
Abstract
Introduction.
Conventional treatments of the periodontitis rely on surgery and antibioticotherapy. The properties of the ozone offer a more innocuous and more economic new alternative therapeutic.
Objective.
To evaluate the effectiveness of the ozone therapy in the treatment of periodontitis type I and II, and to identify the adverse events.
Methods.
It was carried out a clinical trial, phase III, randomized, controlled and to simple blind in patients that went to Odontological Clinic “III Congress of PCC” of Matanzas, January 2013 – January 2015. The sample belonged to 50 patients, divided in 5 groups of 10 patients each one: Group A – Treaties with ozone gas. Group B – OLEOZON®. Group C – ozonized water. Group D – treatment of ozone combined with the three modalities (gas, ozonized water and OLEOZON®. Group Z (control) – conventional treatment. The groups A, B, C and D were the experimental groups. Clinic and microbiolgical evaluation was measures. Effectiveness of the treatment, and adverse events were evaluated. The results showed up in graphics, the percentage and Square Chi were used. The ethical principles were completed.
Results.
Clinical evaluation went satisfactory to the month of the treatment in 84,6% of the studied places, with better results in the group D (96%), with significant differences between the experimental groups and the control. The microbiological evaluation was satisfactory and increased to 85,4% to the six months of the study. The experimental group D prevailed (96,6%). The effectiveness was good in 85,4% of the sample, prevailing in the experimental group D with 96,6%, followed by the group A. The percentage of adverse events was low, 1,5%.
Conclusions.
The clinical and microbiological evaluation showed satisfactory results, associated to a low percentage of adverse events (with gas ozone only). The combined ozone therapy was the most effective treatment for this type of periodontitis.
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Author Biographies
Judit Martinez-Abreu, Director of the Career in Stomatology. Auxiliary Professor. University of Medical Sciences of Matanzas,
Mark T Weisser, Pathfinder Institute. Santa Barbara, California.
Silvia Menendez-Cepero, Centro Nacional de Investigaciones Científicas (CNIC), Havana.
References
Azarpazhooh A, Limeback H. The application of ozone in dentistry: a systematic review of literature. J Dent. 2008;36:104-116.
Lynch E. Ozone: The Revolution in Dentistry. Chicago: Quintessence Publishing; 2004.
Bocci V. Ozone as a bioregulator. Pharmacology and toxicology of ozone therapy today. J Biol Regul Homeost Agents. 1996;10:31-53.
Sagai M, Bocci V. Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress. Med Gas Res. 2011;1(1). doi: 10.1186/2045-9912-1-29.
Garg R, Tandon S. Ozone: A new face of dentistry. The Internet Journal of Dental Science. 2008;7(2). Available from: http://ispub.com/IJDS/7/2/6215
Saini R. Ozone therapy in dentistry: A strategic review. Journal of natural science, biology, and medicine. 2011;2(2):151-153. PubMed PMID: 22346227.
Bhateja S. The miraculous healing therapy? Ozone therapy? In dentistry. Indian Journal of Dentistry. 2012;3(3):150-155.
Bocci V, Zanardi I, Travagli V. Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects. Medical Gas Research. 2011;1(6). doi: 10.1186/2045-9912-1-6.
Loncar B, Stipetic MM, Matosevic D, Tarle Z. Ozone Application in Dentistry. Archives of Medical Research. 2009;40(2):136-137.
Estrela C, Estrela CRA, Decurcio DA, Hollanda ACB, Silva JA. Antimicrobial efficacy of ozonated water, gaseous ozone, sodium hypochlorite and chlorhexidine in infected human root canals. Int Endodont J. 2007;40:85-93.
Menendez S, Fernandez M, Amoroto M, Uranga R, Acuña P, Benitez JE, et al. Eficacia y seguridad del Oleozon® topico en el tratamiento de pacientes con impetigo. Rev Panamericana de Infectologia. 2007;9(2):23-29.
Bocci V. Ozone as Janus: This controversial gas can be either toxic or medically useful. Mediators of Inflammation. 2004;13(1):3-11. doi: 10.1080/0962935062000197083.
Bocci V. Tropospheric Ozone Toxicity vs. Usefulness of Ozone Therapy Arch Medical Res. 2007;38(2):265-267.
Bocci V. Is it true that ozone is always toxic? The end of a dogma. Toxicol Appl Pharmacol. 2006;216(3):493-504.
Cruz O, Menendez S, Reyes O, Díaz W. Aplicación de la ozonoterapia en el tratamiento de los conductos radiculares infectados. Revista Cubana de Estomatología. 1994;31:14-18.
Falcon L, Simon R, Menendez S. Aceite ozonizado en dermatologia. Experiencia de 9 años. Revista CENIC Ciencias Biologicas. 1998;29:192-9.
Menendez S, Falcon L, Simon DR, Landa N. Efficacy of OLEOZON® in the treatment of tinea pedis. Mycoses. 2002;45:329-332.
Amoroto M, Fernandez M, Gonzalez ME, Escobedo A, Palomino A, Acosta M. Eficacia del aceite ozonizado (OLEOZON®) en el tratamiento de la giardiasis. Ensayo clínico fase III, aleatorizado, abierto y controlado. Rev. Cubana de Farmacia. 2002;36(2):173-175.
Garcia E, Roche A, Blanco AC, Rodriguez LO. La ozonoterapia en el tratamiento de la estomatitis subprotesis. Rev Cubana Estomatol. 2003;40(2):6-10.
Lezcano I, Moleiro J, Gomez M. Actividad in vitro del OLEOZON® frente a agentes etiologicos de infecciones en la piel. Revista CENIC Ciencias Biologicas. 1998;29:209-212.
Martinez G, Merino N, Sam S, Cenarega T. Efecto histologico y bioquimico del OLEOZON® en el modelo de la cola de raton. Revista CENIC Ciencias Biologicas. 1997;28:31-35.
Acevedo F, Gonzalez J, Moleiro J. Ensayo de toxicidad dermica de 120 días del aceite ozonizado, OLEOZON®, en ratas Cenp. SPRD. Avances en Biotecnología Moderna. 1997;4.
Arteaga ME, Molerio J, Bada A, Gonzalez B, Zamora Z, Remigio AC. Clasificacion toxicologica del OLEOZON®. Rev CENIC Ciencias Biologicas. 2000;32(1):57-59.
Remigia A, Gonzalez Y, Zamora Z, Molerio J. Evaluacion genotoxica del Oleozon®. Rev CENIC Ciencias Biologicas. 1998;28:100-104.
Martinez G, Leon OS, Rodriguez C, Merino N. Estudio de la toxicidad aguda dermica del aceite ozonizado OLEOZON® en ratas. Revista CENIC Ciencias Biologicas. 1997;28:35-41.
Llerena C, Moleiro J, Garcia C. Prueba de sensibilizacion del aceite ozonizado. Registro medico OLEOZON® pinceladas. Aplicación en epidermofitosis. Registro Sanitario No. 1498. Cuba: Centro para el Control Estatal de Calidad de los Medicamentos de la Republica de Cuba; 1999.
Unknown-authors . Programa Nacional de Medicina Natural y Tradicional. La Habana, Cuba: Editorial Ciencias Medicas; 2008.
Gupta G, Mansi B. Ozone therapy in periodontics. J Med Life. 2012;5(1):59-67. PubMed PMID: 22574088.
Eick S, Tigan M, Sculean A. Effect of ozone on periodontopathogenic species - an in vitro study. Clinical Oral Investigations. 2011;16:537-544.
Johansson E, Claesson R, van-Dijken JW. Antibacterial effect of ozone on cariogenic bacterial species. J Dent. 2009;37:449-453.
Burgassi S, Zanardi I, Travagli V, Montomoli E, Bocci V. How much ozone bactericidal activity is compromised by plasma components. J Appl Microbiol. 2009;106:1715-1721.
Sharma M, Hudson JB. Ozone gas is an effective and practical antibacterial agent. Am J Infect Control. 2008;36:559-563.
Yamada K, Yama M, Takaku Y, Kakizawa T, Kimizuka R, Okuda K, et al. Antimicrobial activity of super-oxidised water against oral microorganisms. Arch Oral Biol. 2010;55:397-400.
Huth KC, Quirling M, Maier S, Kamereck K, Alkhayer M, Paschos E, et al. Effectiveness of ozone against endodontopathogenic microorganisms in a root canal biofilm model. Int Endod J. 2009;42:3-13.
Mayor-Hernandez F, Martinez-Abreu J, Moure-Ibarra MD, Garcia-Valdes MR. Aplicacion del OLEOZON® en el tratamiento de las pericoronaritis. Rev Med Electron. 2011;33(1). Available from: http://www.revmatanzas.sld.cu/revista%20medica/ano%202011/vol1%202011/tema11.htm
Martinez-Abreu J, Chapelin-Arencibia Y, Peña-Ruiz T. OLEOZON® en el tratamiento de la gingivitis cronica edematosa. Rev Med Electron. 2006;28(6). Available from: http://www.cpimtz.sld.cu/revista%20medica/ano%202006/vol6%202006/tema05.htm
Martinez-Abreu J, Peña-Ruiz T, Llanes-Llanes E, Ilzarbe LM. Papel de los metabolitos reactivos del oxigeno en los periodontopatias. Rev Med Electron. 2007;29(5). Available from: http://www.cpimtz.sld.cu/revista%20medica/ano%202007/vol5%202007/tema15.htm
Martinez-Abreu J. OLEOZON® en el tratamiento del absceso periodontal agudo en pacientes diabeticos [thesis]. Cuba: Universidad de Ciencias Medicas de Matanzas; 2009.
Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques JL. Ozone therapy in medicine and dentistry. J Contemp Dent Pract. 2008;9:75-84. PubMed PMID: 18473030.
Dhingra K, Vandana KL. Management of gingival inflammation in orthodontic patients with ozonated water irrigation--a pilot study. Int J Dent Hyg. 2011;9(4):296-302. doi: 10.1111/j.1601-5037.2011.00506.x.
Paduraru A, Lacatusu S, Vataman R. Ozone therapy efficiency and gerovital H3 as an additional way to the complex treatment of periodontal disease. Rev Med Chir Soc Med Nat Iasi. 2010;114(3):880-884. PubMed PMID: 21243820.
Ripamonti CI, Cislaghi E, Mariani L, Maniezzo M. Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study. Oral Oncol. 2011;47(3):185-190. PubMed PMID: 2131065.
Polydorou O, Halili A, Wittmer A, Pelz K, Hahn P. The antibacterial effect of gas ozone after 2 months of in vitro evaluation. Clin Oral Investig. 2012;16(2):545-550. PubMed PMID: 21331635.
Ripolles-de-Ramon J, Colmenero-Ruiz C, Gallut-Ruiz J, Zaera-Le-Gal R, Bastones-Martinez A. Evaluacion clinica, microbiologica e inmunologica de la ozonoterapia en pacientes con bolsas periodontales moderadas-severas. Av Periodon Implantol. 2004;16(1):63-72.
Bette M, Mutters R, Nusing RM, Rodríguez ZZ, Menendez S, Schulz S. Efficiency of Piperacillin/Tazobactam in lethal peritonitis is enhanced after preconditioning of rats with an oxidative stressor. Shock. 2006;25(1):23-29.
Zamora Z, Borrego A, Lopez O, Delgado R, Gonzalez R, Menendez S, et al. Effects of ozone oxidative preconditioning on TNF-alfa release and antioxidant-prooxidant intracellular balance in mice during endotoxic shock. Mediators of Inflammation. 2005;1:16-22.
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