Ozone therapy as complementary treatment for surgical infection: case report.
DOI:
https://doi.org/10.7203/jo3t.4.5.2020.18022Keywords:
ozone therapy, surgery, infectionAbstract
Background: Infection is a serious surgical complication that increases significantly morbidity and mortality rates as well as health care expenses. Bacterial ever-growing resistance to antibiotics makes the treatment of such events even more troublesome. Objective: Report on a surgical infection case treated with ozone as a complementary therapy. Methods and Materials: Female, 65 years old, submitted to a complex surgical procedure for adult kyphotic deformity correction that presented with early post-surgical infection. The patient was treated with revision surgery and antibiotics that improved the condition but were unable to delete the infection. Ozone, in its gaseous form, was injected subcutaneously and paravertebraly twice weekly for three weeks. Results: After 3 weeks of treatment the wound healed completely and repeated visits and blood exams up to one year after the surgery did not show recurrence of infection. Conclusions: Although not a definite indication on validity of ozone therapy for surgical infections, the results of this case report indicate a new way that merits to be explored.Downloads
References
Calderone RR, Garland DE, Capen DA, Oster H. Cost of medical care for postoperative spinal infections. OrthopClin North Am. 1996 Jan;27:171–182.
Olsen MA, Mayfield J, Lauryssen C, Polish LB, Jones M, Vest J, Fraser VJ. Risk factors for surgical site infection in spinal surgery. J Neurosurg. 2003 Mar;98:149-155.
Pull terGunne AF, van Laarhoven CJHM, Cohen DB. Incidence of surgical site infection following adult spinal deformity surgery: an analysis of patient risk. Eur Spine J. 2010 Jun;19:982-988.
Picada R, Winter RB, Lonstein JE, Denis F, Pinto MR, Smith MD. Postoperative deep wound infection in adults afterposterior lumbosacral spine fusion with instrumentation: incidence and management. J Spinal Disord. 2000 Feb;13:42–45.
Gaynes RP, Culver DH, Horan TC, Edwards JR, Richards C, Tolson JS. Surgical site infection (SSI) rates in the United States, 1992–1998: the National Nosocomial Infections Surveillance System basic SSI risk index. Clin Infect Dis. 2001 Sep;33:S69–77.
Bowler PG, Deurden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. CliMicrobiol Rev. 2001 Apr;14(2):244-269.
Raahave D, Friis-Moller A, Bjerre-Jespen K, Thiis-Knudsen J, Rasmussen LB. The infective dose of aerobic and anaerobic bacteria in postoperative wound sepsis. Arch Surg, 1986 Aug;121:924–929.
Duerden BI. Virulence factors in anaerobes. Clin Infect Dis. 1994 May;18:S253–S259.
Fang A, Hu SS, Endres N, Bradford DS. Risk Factors for Infection After Spinal Surgery. Spine. 2005 Jun;30(12):1460-1465.
Olsen MA, Nepple JJ, Riew KD, Lenke L, Bridwell KH, Mayfield J, Fraser VJ. Risk factors for surgical site infection following orthopaedic spinal operations. The Journal of Bone and Joint Surgery. 2008 Jan;90(1):62-69.
Saleh K, Sonesson A, Persson B, Riesbeck K, Schmidtchen A. A descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgery. DermatolSurg. 2011 Jun;37(7):1014-1022.
Turtiainen J, Hakala T, Hakkarainen T, Karhukorpi J. The Impact of Surgical Wound Bacterial Colonization on the Incidence of Surgical Site Infection After Lower Limb Vascular Surgery: A Prospective Observational Study. European Journal of Vascular and Endovascular Surgery. 2014 Apr;47(4):411-417.
Lineaweaver WC, Jacob S, Yan H, Zhang F. Wound cultures as predictors of complications in reconstructive flap procedures. Ann PlastSurg. 2011 Aug;66(5):572-574.
Bermond CV. A Review paper: The use of ozone and associated oxidation processes in drinking water treatment. Wat Res. 1998 Mar;32(11):3208-3222.
Guzel-seydim ZB, Greene AK, Seydim AC. Use of ozone in the food industry. LWT-Food Science and Technology. 2004 Oct;34(49):453-460.
Shinriki N. Mechanism with Ozone. Reports of HNIRI. 1994;61:15–36.
Hems RS, Gulabivala K, Ng Y-L, Ready D, Spratt DA. An in vitro evaluation of the ability of ozone to kill a strain of Enterococcus faecalis. Int Endodontic Journal. 2005 Jan;38:22-29.
Marrie TJ, Costerton JW. Mode of growth of bacterial pathogens in chronic polymicrobial human osteomyelitis. J Clin Microbiology. 1985 Dec;22:924–933.
Huth KC, Quirling M, Maier S, Kamereck K, Alkhayer M, Paschos E, Welsch U, Miethke T, Brand K, Hickel R. Effectiveness of ozone against endodontopathogenic microorganisms in a root canal biofilm model. IntEndod J. 2009 Jan;42(1):3-13.
Al-Saadi H, Potapova I, Rochford ET, Moriarty TF, Messmer P. Ozonated saline shows activity against planktonic and biofilm growing Staphylococcus aureus in vitro: a potential irrigant for infected wounds. Int Wound J. 2015 Jan; 13(5):936-942.
Bialoszewski D, Pietruczuk-Padzik A, Kalicinska A, Bocian E, Czajkowska M, Bukowska B, Tyski S. Activity of ozonated water and ozone against Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Medical Science Monitor. International Medical Journal of Experimental and Clinical Research. 2011 Nov;17(11):BR339-344.
Koyama R, Okuda K-I, Kazuhiko M, Monroe B, Yoshimitsu M. Antimicrobial and Antibiofilm Effects of Ozonated Water for Prevention and Treatment of Bone and Joint Infections. Journal of St. Marianna University. 2015;6(1):1-7.
Tachikawa M, Tezuka M, Yamanaka K, Nakamuro K. Studies on the evaluation of disinfections and removal of biofilms by ozone water using a microbial model system. Bull Med &Hyg Ozone Res. 2006;13:50–56.
Broadwater WT, Hoehn RC, King PH. Sensitivity of three selected bacterial species to ozone. Applied Microbiology. 1973 Sep;26:391-393.
Hoshi S, Sakura M, Kitagawa S, Mori K, Saitou A, Akabori Y, Murakami A. Toxicity Study of Ozonized Water. Journal of Shizuoka Saisei Medicine. 1995;12: 89–95.
Ventola C. The Antibiotic Resistance Crisis Part 1: Causes and Threats. P T. 2015 Apr;40(4):277–283.
Harold CN. The Crisis in Antibiotic Resistance. Science. 1992;257:1064-1073.
Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat SciBiol Med. 2011 Jan;2(1):66–70.
Bulent U, Mehmet Y, Nail E, Omer C, Abdullah K, Tuncer C, Bulent K, Sukru O, Ahmet K, Ahmet G. Efficacy of Hyperbaric Oxygen Therapy and Medical Ozone Therapy in Experimental Acute Necrotizing Pancreatitis. Pancreas. 2010 Jan;39:9-15.
Białoszewski D. The use of the intraooperative ozone - theraphy as prophylaxis of infections in surgery of locomotor system with special regard to total hip plasty - a preliminary study. Ortop Traumatol Rehabil. 2003 Dec;5(6):781-786.
Białoszewski D, Kowalewski M. Superficially, longer, intermittent ozone theraphy in the treatment of the chronic, infected wounds. Ortop Traumatol Rehabil. 2003 Oct;5(5):652-658.
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