A diseased ecosystem: Tackling antibiotic resistance from a global perspective

Authors

  • Fernando Baquero Ramón y Cajal Institute of Health Research (IRYCIS), Madrid (Spain).
  • Maria Carmen Turrientes Ramón y Cajal Institute of Health Research (IRYCIS), Madrid (Spain).

DOI:

https://doi.org/10.7203/metode.78.2627

Keywords:

eco-evo strategies, global medicine, antibiotic resistance, multi-hierarchical analysis

Abstract

Man’s production of antibiotics has led to disease in microbial ecosystems on a planetary scale. The most immediate impact for man is the intractability of infections. To tackle this we must improve our understanding of this phenomenon, and develop intervention strategies employing novel conceptual, analytical and technological methods.

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Author Biographies

Fernando Baquero, Ramón y Cajal Institute of Health Research (IRYCIS), Madrid (Spain).

Scientific Director of the Ramón y Cajal Institute of Health Research (IRYCIS), Madrid (Spain).

Maria Carmen Turrientes, Ramón y Cajal Institute of Health Research (IRYCIS), Madrid (Spain).

Researcher at the Department of Microbiology. Ramón y Cajal Institute of Health Research (IRYCIS), Madrid (Spain).

References

Bapteste, E. et al., 2012. «Evolutionary Analyses of Non-genealogical Bonds Produced by Introgressive Descent». PNAS, 109(45): 18266-18272. DOI: <10.1073/pnas.1206541109>.

Baquero, F.; Coque, T. M. and F. de la Cruz, 2011. «Ecology and Evolution as Targets: the Need for Novel Eco-evo Drugs and Strategies to Fight Antibiotic Resistance». Antimicrob Agents Chemother, 55(8): 3649-3660. DOI: <10.1128/AAC.00013-11>.

Baquero, F.; Martínez, J. L. and R. Cantón, 2008. «Antibiotics and Antibiotic Resistance in Water Environments». Current Opinion in Biotechnology, 19: 260-265. DOI: <10.1016/j.copbio.2008.05.006>.

Baquero, F.; Tedim, A. P. and T. M. Coque, 2013. «Antibiotic Resistance Shaping Multilevel Population Biology of Bacteria». Frontiers in Antimicrobials, Resistance and Chemotherapy. Pre-published online: 6 March 2013. DOI: <10.3389/ fmicb.2013.00015>.

Levy, S. B., 2002. The Antibiotic Paradox. Da Capo Press. Cambridge, MA. Galán, J. C.; González-Candelas, F.; Rolain, J. M. and R. Cantón, 2013. «Antibiotics as Selectors and Accelerators of Diversity in the Mechanisms of Resistance: from the Resistome to Genetic Plasticity in the β-lactamases World». Frontiers in Antimicrobials, Resistance and Chemotherapy. Published online: 8 February 2013. DOI: <10.3389/fmicb.2013.00009>.

Linares, J. F.; Gustafsson, I.; Baquero, F. and J. L. Martínez, 2006. «Antibiotics as Intermicrobial Signaling Agents Instead of Weapons». PNAS, 103(51): 19484-19489. DOI: <10.1073/pnas.0608949103>.

Published

2014-06-01

How to Cite

Baquero, F., & Turrientes, M. C. (2014). A diseased ecosystem: Tackling antibiotic resistance from a global perspective. Metode Science Studies Journal, (4), 87–91. https://doi.org/10.7203/metode.78.2627
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Section

In light of evolution. Making sense of biotech applications

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