Diverse ways to think about cancer: What can we learn about cancer by studying it across the tree of life?

Authors

DOI:

https://doi.org/10.7203/metode.10.14593

Keywords:

cancer, Peto’s paradox, life history, multicellularity, ageing

Abstract

When asked about cancer, most would first think of it as a devastating disease. Some might add that lifestyle (e.g., smoking) or environmental pollution has something to do with it, but also that it tends to occur in old people. Cancer is indeed one of the most common causes of death in humans, and its incidence increases with age. Yet, focusing on our own species, we tend to overlook something very elementary: cancer is not unique to humans. In fact, it is a phenomenon that unifies diverse branches of the tree of life. Exploring the diversity of ways in which different organisms cope with it can lend us novel insights on cancer. In turn, by acknowledging cancer as a selective pressure, we can better understand the evolution of the biodiversity that surrounds us.

Downloads

Download data is not yet available.

Author Biographies

E. Yagmur Erten, Department of Evolutionary Biology at the University of Zurich (Switzerland).

PhD student in Evolutionary Biology at the University of Zurich (Switzerland). Mainly interested in using mathematical and computational models to study evolutionary questions. She is currently working on modelling life history evolution under cancer risk. During her Master’s Degree within the programme MEME (Erasmus Mundus Master Programme in Evolutionary Biology), she worked on cultural evolution and evolutionary epidemiology.  

Hanna Kokko, Department of Evolutionary Biology at the University of Zurich (Switzerland).

Professor of Evolutionary Ecology at the University of Zurich (Switzerland), where she landed in 2014 after an Australian Laureate Fellowship. She completed her PhD in 1997 at Helsinki University (Finland). She has a longstanding interest in the mathematical logic that underpins biology, and is interested in cancer as a life history phenomenon since her stay at the Institute for Advanced Study in Berlin (Germany) in 2014.

References

Abegglen, L. M., Caulin, A. F., Chan, A., Lee, K., Robinson, R., Campbell, M. S., … Schiffman, J. D. (2015). Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. Journal of the American Journal Association, 314(17), 1850–1860. doi: 10.1001/jama.2015.13134

Aktipis, C. A., Boddy, A. M., Jansen, G., Hibner, U., Hochberg, M. E., Maley, C. C., & Wilkinson, G. S. (2015). Cancer across the tree of life: Cooperation and cheating in multicellularity. Philosophical Transactions of the Royal Society B, 370(1673), 20140219. doi: 10.1098/rstb.2014.0219

Blanckenhorn, W. U. (2000). The evolution of body size: What keeps organisms small? The Quarterly Review of Biology, 75(4), 385–407. doi: 10.1086/393620

Brown, J. S., Cunningham, J. J., & Gatenby, R. A. (2015). The multiple facets of Peto’s paradox: A life-history model for the evolution of cancer suppression. Philosophical Transactions of the Royal Society B, 370(1673), 20140221. doi: 10.1098/rstb.2014.0221

Effron, M., Griner, L., & Benirschke, K. (1977). Nature and rate of neoplasia found in captive wild mammals, birds, and reptiles at necropsy. Journal of the National Cancer Institute, 59(1), 185–198. doi: 10.1093/jnci/59.1.185

Giraudeau, M., Sepp, T., Ujvari, B., Ewald, P. W., & Thomas, F. (2018). Human activities might influence oncogenic processes in wild animal populations. Nature Ecology & Evolution, 2(7), 1065–1070. doi: 10.1038/s41559-018-0558-7

Hochberg, M. E., & Noble, R. J. (2017). A framework for how environment contributes to cancer risk. Ecology Letters, 20(2), 117–134. doi: 10.1111/ele.12726

Kingsolver, J. G., & Pfennig, D. W. (2004). Individual-level selection as a cause of Cope’s rule of phyletic size increase. Evolution, 58(7), 1608–1612. doi: 10.1554/04-003

Kokko, H., & Hochberg, M. E. (2015). Towards cancer-aware life-history modelling. Philosophical Transactions of the Royal Society B, 370(20140234). doi: 10.1098/rstb.2014.0234

Lee, M. S. Y., Cau, A., Naish, D., & Dyke, G. J. (2014). Sustained miniaturization and anatomical innovation in the dinosaurian ancestors of birds. Science, 345(6196), 562–566. doi: 10.1126/science.1252243

Nunney, L. (2018). Size matters: Height, cell number and a person’s risk of cancer. Proceedings of the Royal Society B: Biological Sciences, 285(1889), 20181743. doi: 10.1098/rspb.2018.1743

Peto, R. (1977). Epidemiology, multistage models, and short-term mutagenicity tests. In H. Hiatt, J. Watson, & J. Winsten (Eds.), Origins of human cancer(pp. 1403–1428). New York: Cold Spring Harbor Laboratory Press.

Seluanov, A., Gladyshev, V. N., Vijg, J., & Gorbunova, V. (2018). Mechanisms of cancer resistance in long-lived mammals. Nature Reviews Cancer, 18(7), 433–441. doi: 10.1038/s41568-018-0004-9

Tollis, M., Schiffman, J. D., & Boddy, A. M. (2017). Evolution of cancer suppression as revealed by mammalian comparative genomics. Current Opinion in Genetics & Development, 42, 40–47. doi: 10.1016/j.gde.2016.12.004

Vazquez, J. M., Sulak, M., Chigurupati, S., & Lynch, V. J. (2018). A zombie LIF gene in elephants is upregulated by TP53 to induce apoptosis in response to DNA damage. Cell Reports, 24(7), 1765–1776. doi: 10.1016/j.celrep.2018.07.042

Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz Jr, L. A., & Kinzler, K. W. (2013). Cancer genome landscapes. Science, 339(6127), 1546–1558. doi: 10.1126/science.1235122

Downloads

Additional Files

Published

2020-01-08

How to Cite

Erten, E. Y., & Kokko, H. (2020). Diverse ways to think about cancer: What can we learn about cancer by studying it across the tree of life?. Metode Science Studies Journal, (10), 201–205. https://doi.org/10.7203/metode.10.14593
Metrics
Views/Downloads
  • Abstract
    1555
  • PDF
    595
  • (Español)
    3

Issue

Section

Endless forms. Evolutionary scenarios to unravel biodiversity

Metrics

Similar Articles

<< < > >> 

You may also start an advanced similarity search for this article.