Una progènie espantosa? El futur del cultiu d’humans

Autors/ores

  • Philip Ball Escriptor i comunicador científic (Londres, Regne Unit).

DOI:

https://doi.org/10.7203/metode.12.20651

Paraules clau:

enginyeria de teixits, cèl·lules mare, organoides, reprogramació cel·lular, transhumanisme

Resum

Les biotecnologies actuals no sols ofereixen noves possibilitats per a la medicina, també estan transformant el que entenem per ser humà. Concretament, el descobriment de l’extrema plasticitat de les cèl·lules –la possibilitat d’intercanviar tipus de teixits i de regenerar l’estat cel·lular embrionari a partir del qual creixem– ens obliga a enfrontar-nos al fet que som una comunitat contingent de cèl·lules vives, i desafia les idees tradicionals d’autoconsciència i identitat. En aquest article s’exploren algunes d’aquestes tecnologies i les seues implicacions socials, ètiques i filosòfiques.

Descàrregues

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Biografia de l'autor/a

Philip Ball, Escriptor i comunicador científic (Londres, Regne Unit).

Escriptor i comunicador científic (Londres, Regne Unit). Ha treballat com a editor en Nature. Entre els seus molts llibres sobre la ciència i les seues interaccions amb la cultura general destaquen Al servicio del Reich. La física en tiempos de Hitler (2014), Cuántica: Qué significa la teoría de la ciencia más extraña (2018) y Cómo crear un ser humano (2019), tots publicats en castellà per l’editorial Turner Libros. 

Referències

Aach, J., Lunshof, J., Iyer, E., & Church, G. M. (2017). Addressing the ethical issues raised by synthetic human entities with embryo-like features. eLife, 6, e20674. https://doi.org/10.7554/eLife.20674

Adli, M. (2018). The CRISPR tool kit for genome editing and beyond. Nature Communications, 9, 1911. https://doi.org/10.1038/s41467-018-04252-2

Bernal, J. D. (1970). The world, the flesh and the devil: An enquiry into the future of the three enemies of the rational soul. Jonathan Cape. (Original work published in 1931).

Boland, M. J., Hazen, J. L., Nazor, K. L., Rodriguez, A. R., Gifford, W., Martin, G., Kupriyanov, S., & Baldwin, K. K. (2009). Adult mice generated from induced pluripotent stem cells. Nature, 461, 91–94. https://doi.org/10.1038/nature08310

Greely, H. T. (2016). The end of sex and the future of human reproduction. Harvard University Press.

Greely, H. T. (2021). CRISPR people: The science and ethics of editing humans. MIT Press.

Harrison, S. E., Sozen, B., Christodoulou, N., Kyprianou, C., & Zernicka-Goetz, M. (2017). Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science, 356(6334), eaal1810. https://doi.org/10.1126/science.aal1810

Kim, J., Koo, B. K., & Knoblich, J. A. (2020). Human organoids: Model systems for human biology and medicine. Nature Reviews Molecular Cell Biology, 21, 571–584. https://doi.org/10.1038/s41580-020-0259-3

Kojima, J., Fukuda, A., Taira, H., Kawasaki, T., Ito, H., Kuji, N., Isaka, K., Umezawa, A., & Akutsu, H. (2017). Efficient production of trophoblast lineage cells from human induced pluripotent stem cells. Laboratory Investigation, 97, 1188–1200. https://doi.org/10.1038/labinvest.2016.159

Li, F., Hu, J., & He, T.-C. (2017). iPSC-based treatment of age-related macular degeneration (AMD): The path to success requires more than blind faith. Genes & Disease, 4(2), 41–42. https://doi.org/10.1016/j.gendis.2017.03.001

More, M., & Vita-More, N. (Eds.). (2013). The transhumanist reader. Wiley-Blackwell.

Nagoshi, N., Tsuji, O., Nakamura, M., & Okano, H. (2019). Cell therapy for spinal cord injury using induced pluripotent stem cells. Regenerative Therapy, 11, 75–80. https://doi.org/10.1016/j.reth.2019.05.006

Payne, N. L., Sylvain, A., O’Brien, C., Herszfeld, D., Sun, G., & Bernard, C. C. A. (2015). Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases. New Biotechnology, 32(1), 212–228. https://doi.org/10.1016/j.nbt.2014.05.001

Pera, M. (2017). Embryogenesis in a dish. Science, 356(6334), 137–138. https://doi.org/10.1126/science.aan1495

Saitou, M., & Miyauchi, H. (2016). Gametogenesis from pluripotent stem cells. Cell Stem Cell, 18(6), 721–735. https://doi.org/10.1016/j.stem.2016.05.001

Simunovic, M., & Brivanlou, A. H. (2017). Embryoids, organoids and gastruloids: New approaches to understanding embryogenesis. Development, 144(6), 976–985. https://doi.org/10.1242/dev.143529

Squier, S. M. (2004). Liminal lives: Imagining the human at the frontiers of Biomedicine. Duke University Press. https://doi.org/10.1215/9780822386285

Tang, P. C., Hashino, E., & Nelson, R. F. (2020). Progress in modeling and targeting inner ear disorders with pluripotent stem cells. Stem Cell Reports, 14(6), 996–1008. https://doi.org/10.1016/j.stemcr.2020.04.008

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomodad, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861–872. https://doi.org/10.1016/j.cell.2007.11.019

Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663–676. https://doi.org/10.1016/j.cell.2006.07.024

Aach, J., Lunshof, J., Iyer, E., & Church, G. M. (2017). Addressing the ethical issues raised by synthetic human entities with embryo-like features. eLife, 6, e20674. https://doi.org/10.7554/eLife.20674Adli, M. (2018). The CRISPR tool kit for genome editing and beyond. Nature Communications, 9, 1911. https://doi.org/10.1038/s41467-018-04252-2Bernal, J. D. (1970). The world, the flesh and the devil: An enquiry into the future of the three enemies of the rational soul. Jonathan Cape. (Original work published in 1931).Boland, M. J., Hazen, J. L., Nazor, K. L., Rodriguez, A. R., Gifford, W., Martin, G., Kupriyanov, S., & Baldwin, K. K. (2009). Adult mice generated from induced pluripotent stem cells. Nature, 461, 91–94. https://doi.org/10.1038/nature08310Greely, H. T. (2016). The end of sex and the future of human reproduction. Harvard University Press.Greely, H. T. (2021). CRISPR people: The science and ethics of editing humans. MIT Press.Harrison, S. E., Sozen, B., Christodoulou, N., Kyprianou, C., & Zernicka-Goetz, M. (2017). Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science, 356(6334), eaal1810. https://doi.org/10.1126/science.aal1810Kim, J., Koo, B. K., & Knoblich, J. A. (2020). Human organoids: Model systems for human biology and medicine. Nature Reviews Molecular Cell Biology, 21, 571–584. https://doi.org/10.1038/s41580-020-0259-3Kojima, J., Fukuda, A., Taira, H., Kawasaki, T., Ito, H., Kuji, N., Isaka, K., Umezawa, A., & Akutsu, H. (2017). Efficient production of trophoblast lineage cells from human induced pluripotent stem cells. Laboratory Investigation, 97, 1188–1200. https://doi.org/10.1038/labinvest.2016.159Li, F., Hu, J., & He, T.-C. (2017). iPSC-based treatment of age-related macular degeneration (AMD): The path to success requires more than blind faith. Genes & Disease, 4(2), 41–42. https://doi.org/10.1016/j.gendis.2017.03.001More, M., & Vita-More, N. (Eds.). (2013). The transhumanist reader. Wiley-Blackwell.Nagoshi, N., Tsuji, O., Nakamura, M., & Okano, H. (2019). Cell therapy for spinal cord injury using induced pluripotent stem cells. Regenerative Therapy, 11, 75–80. https://doi.org/10.1016/j.reth.2019.05.006Payne, N. L., Sylvain, A., O’Brien, C., Herszfeld, D., Sun, G., & Bernard, C. C. A. (2015). Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases. New Biotechnology, 32(1), 212–228. https://doi.org/10.1016/j.nbt.2014.05.001Pera, M. (2017). Embryogenesis in a dish. Science, 356(6334), 137–138. https://doi.org/10.1126/science.aan1495Saitou, M., & Miyauchi, H. (2016). Gametogenesis from pluripotent stem cells. Cell Stem Cell, 18(6), 721–735. https://doi.org/10.1016/j.stem.2016.05.001Simunovic, M., & Brivanlou, A. H. (2017). Embryoids, organoids and gastruloids: New approaches to understanding embryogenesis. Development, 144(6), 976–985. https://doi.org/10.1242/dev.143529Squier, S. M. (2004). Liminal lives: Imagining the human at the frontiers of biomedicine. Duke University Press. https://doi.org/10.1215/9780822386285Tang, P. C., Hashino, E., & Nelson, R. F. (2020). Progress in modeling and targeting inner ear disorders with pluripotent stem cells. Stem Cell Reports, 14(6), 996–1008. https://doi.org/10.1016/j.stemcr.2020.04.008Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomodad, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861–872. https://doi.org/10.1016/j.cell.2007.11.019Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663–676. https://doi.org/10.1016/j.cell.2006.07.024

 

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2022-02-02

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Ball, P. (2022). Una progènie espantosa? El futur del cultiu d’humans. Metode Science Studies Jornal, (12), 153–159. https://doi.org/10.7203/metode.12.20651
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