One of the foremost experiments of the 20th century

Autores/as

  • Jeff L. Bada University of California, San Diego

DOI:

https://doi.org/10.7203/metode.6.4994

Palabras clave:

amino acids, spark discharge, reducing atmosphere

Resumen

Stanley Miller is best known for his classic 1953 experiment on organic compound synthesis on the early Earth in the context of the origins of life. However, he did several other experiments that are lesser known and in some cases never published. The finding in 2007 that Miller had archived dried solutions from his 1950s experiments offered the opportunity to analyse the products of his early experiments using modern day state-of-the-art techniques. These results along with Miller’s results, have provided an inventory of the large variety of compounds, that include amino acids, amines, simple peptides, hydroxy acids, simple hydrocarbons and 1urea, that can be synthesized under simulated early Earth conditions.

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Biografía del autor/a

Jeff L. Bada, University of California, San Diego

Jeffrey Bada is a Distinguished Research Professor, and Distinguished Professor Emeritus, of Marine Chemistry at the Scripps Institution of Oceanography, University of California, San Diego. He obtained his PhD in Chemistry at UCSD in 1968 where Stanley Miller supervised his thesis research. His research deals with the environments on the early Earth that provided the optimal conditions for the synthesis of organic compounds required for the origin of life

Citas

Bada, J. L. (2013). New insights into prebiotic chemistry from Stanley Miller’s spark discharge experiments. Chemical Society Reviews, 42, 2186–2196. doi: 10.1039/c3cs35433d

Bada, J. L., & Lazcano, A. (2002). Miller revealed new ways to study the origins of life. Nature, 416, 475. doi: 10.1038/416475a

Bada, J. L., & Lazcano, A. (2003). Prebiotic soup – Revisiting the Miller experiment. Science, 300, 745–746. doi: 10.1126/science.1085145

Bada, J. L., & Lazcano, A. (2012). Stanley L. Miller (1930-2007): A biographical memoir. Retrieved from the National Academy of Sciences (USA) website: http://www.nasonline.org/memoirs

Ball, P. (2005). Elegant solutions. London: Royal Society of Chemistry. doi: 10.1039/9781847552600

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Cavendish, H. (1788). On the conversion of a mixture of dephlogisticated and phlogisticated air into nitrous acid, by the electric spark. Philosophical Transactions of the Royal Society of London, 78, 261–276.

Fekete, B. M., Vörösmarty, C. J., & Grabs, W. (2002). High‐resolution fields of global runoff combining observed river discharge and simulated water balances. Global Biogeochemical Cycles, 16(3), 1–10. doi: 10.1029/1999GB001254

Johnson, A. P., Cleaves, H. J., Dworkin, J. P., Glavin, D. P., Lazcano, A., & Bada, J. L. (2008). The Miller volcanic spark discharge experiment. Science, 322, 404. doi: 10.1126/science.1161527

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Miller, S. L. (1953). A production of amino acids under possible primitive earth conditions. Science, 117, 528–529. doi: 10.1126/science.117.3046.528

Miller, S. L. (1955). Production of some organic compounds under possible primitive earth conditions. Journal of the American Chemical Society, 77, 2351–2361. doi: 10.1021/ja01614a001

Miller, S. L. (1957). The mechanism of synthesis of amino acids by electric discharges. Biochimica et Biophysica Acta, 23, 480–489. doi: 10.1016/0006-3002(57)90366-9

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Parker, E. T., Cleaves, H. J., Dworkin, J. P., Glavin, D. P., Callahan, M., Aubrey, A., Lazcano, A., & Bada, J. L. (2011). Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment. Proceedings of the National Academy of Sciences, 108, 5526–5531. doi: 10.1073/pnas.1019191108

Parker, E. T., Zhou, M., Burton, A. S., Glavin, D. P., Dworkin, J. P., Krishnamurthy, R., Fernández, F. M., & Bada, J. L. (2014). A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth. Angewandte Chemie, 126, 8270–8274. doi: 10.1002/ange.201403683

Peltzer, E. T., Bada, J. L., Schlesinger, G., & Miller, S. L. (1984). The chemical conditions on the parent body of the Murchison meteorite: Some conclusions based on amino, hydroxy and dicarboxylic acids. Advances in Space Research, 4, 69–74. doi: 10.1016/0273-1177(84)90546-5

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Weber, A. L., & Pizzarello, S. (2006). The peptide-catalyzed stereospecific synthesis of tetroses: A possible model for prebiotic molecular evolution. Proceedings of the National Academy of Sciences, 103, 12713–12717. doi: 10.1073/pnas.0602320103

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Publicado

15-04-2016

Cómo citar

Bada, J. L. (2016). One of the foremost experiments of the 20th century. Metode Science Studies Journal, (6), 183–189. https://doi.org/10.7203/metode.6.4994
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On the origin of life. An incomplete scientific story

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